Monday, December 10, 2018

Research Centre: Birmingham, Alabama



Publication List:

  1. Julian, B.A., Tomana, M., Novak, J., Mestecky, J. Progress in the pathogenesis of IgA nephropathy. Adv. Nephrol. 29, 53-72, 1999.
  2. Tomana, M., Novak, J., Julian, B. A., Matousovic, K., Konecny, K., Mestecky, J. Circulating immune complexes in IgA nephropathy consist of IgA1 with galactose-deficient hinge region and antiglycan antibodies. J. Clin. Invest. 104, 73-81, 1999.
  3. Novak, J., Tomana, M., Kilian, M., Coward, L., Kulhavy, R., Barnes, S., Mestecky, J. Heterogeneity of O-glycosylation in the hinge region of human IgA1. Mol. Immunol. 37, 1047-1056, 2000.
  4. Novak, J., Julian, B.A., Tomana, M., Mestecky, J. Progress in molecular and genetic studies of IgA nephropathy. J. Clin. Immunol. 21, 310-327, 2001.
  5. Novak, J., Vu, H.L., Novak, L., Julian, B., Mestecky, J., Tomana, M. Interactions of human mesangial cells with IgA and IgA-containing circulating immune complexes. Kidney Int. 62, 465-475, 2002.
  6. Mestecky, J., Novak, J., Julian, B.A., Tomana, M. Pathogenic potential of galactose-deficient IgA1 in IgA nephropathy. Nephrology 7, S92-S99, 2002.
  7. Moura, I.C., Arcos-Fajardo, M., Leroy, V., Benhamou, M., Novak, J., Haddad, E., Chintalacharuvu, K.R., Monteiro, R.C. Glycosylation and size of IgA1 are essential for interaction with mesangial transferrin receptor in IgA nephropathy. J. Am. Soc. Nephrol. 15, 622-634, 2004.
  8. Julian, B.A., Novak, J. IgA nephropathy: an update. Invited article. Current Opin. Nephrol. Hypertens. 13, 171-179, 2004.
  9. Novak, J., Tomana, M., Matousovic, K., Brown, R., Hall, S., Novak, L., Julian, B.A., Wyatt, R.J., Mestecky, J. IgA1-containing immune complexes in IgA nephropathy differentially affect proliferation of mesangial cells. Kidney Int. 67, 504-513, 2005.
  10. Renfrow, M.B., Cooper, H.J., Tomana, M., Kulhavy, R., Hiki, Y., Toma, K., Emmett, M.R., Mestecky, J., Marshall A. G., Novak, J. Determination of aberrant O-glycosylation in the IgA1 hinge region by electron capture dissociation Fourier transform ion cyclotron resonance mass spectrometry. J. Biol. Chem. 280, 19136-19145, 2005.
  11. Matousovic, K., Novak, J., Yanagihara, T., Tomana, M., Moldoveanu, Z., M., Kulhavy, R., Julian, B.A., Konecny, K., Mestecky, J. IgA1-containing immune complexes in the urine of IgA nephropathy patients. Nephrol. Dial. Transplant. 21, 2478-84, 2006.
  12. Moore, J.S., Kulhavy, R., Tomana, M., Moldoveanu, Z., Suzuki, H., Brown, R., Hall, S., Kilian, M., Poulsen, K., Mestecky, J., Julian, B.A., and Novak, J. Reactivities of N-acetylgalactosamine-specific lectins with human IgA1 proteins. Mol. Immunol. 44, 2598-2604, 2007.
  13. Mischak, H., Apweiler, R., Banks, R.E., Conaway, M., Coon, J., Dominiczak, A., Ehrich, J.H.H., Fliser, D., Girolami, M., Hermjakob, H., Hochstrasser, D., Jankowski, J., Julian, B.A., Kolch, W., Massy, Z.A., Neusuess, C., Novak, J., Peter, K., Rossing, K., Schanstra, J., Semmes, J.O., Theodorescu, D., Thongboonkerd, V., Weissinger, E., Van Eyk, J.E., and Yamamoto, T. Clinical Proteomics: A need to define the field and to begin to set adequate standards. Proteomics-Clin. Appl. 1, 148-156, 2007.
  14. Fliser, D., Novak, J., Thongboonkerd, V., Argilés, À., Jankowski, V., Girolami, M.A., Jankowski, J., Mischak, H. Advances in urinary proteome analysis and biomarker discovery. J. Am. Soc. Nephrol. 18, 1057-1071, 2007.
  15. Moldoveanu, Z., Wyatt, R.J., Lee, J., Tomana, M., Julian, B.A., Mestecky, J., Huang, W.-Q., Anreddy, S., Hall, S., Hastings, M.C., Lau, K.K., Cook, W.J., Novak, J. Patients with IgA nephropathy have increased serum galactose-deficient IgA1 levels. Kidney Int. 71, 134-138, 2007.
  16. Mischak, H., Julian, B.A., Novak, J. High-resolution proteome/peptidome analysis of peptides and low-molecular-weight proteins in urine. Proteomics-Clin. Appl. 1, 792-804, 2007.
  17. Beerman, I., Novak, J., Wyatt, R.J., Julian, B.A., Gharavi, A.G. Genetics of IgA nephropathy. Nat. Clin. Pract. Nephrol. 3, 325-338, 2007.
  18. Raska, M., Moldoveanu, Z., Suzuki, H., Brown, R., Kulhavy, R., Andrasi, J., Hall, S., Vu, H.L., Carlsson, F., Lindahl, G., Tomana, M., Julian, B.A., Wyatt, R.J., Mestecky, J., and Novak, J. Identification and characterization of CMP-NeuAc:GalNAc-IgA1 α2,6-sialyltransferase in IgA1-producing cells. J. Mol. Biol. 369, 69-78, 2007.
  19. Julian, B.A., Wittke, S., Haubitz, M., Zürbig, P., Schiffer, E., McGuire, B.M., Wyatt, R.J., Novak, J. Urinary biomarkers of IgA nephropathy and other IgA-associated renal diseases. World J. Urol. 25, 467-476, 2007.
  20. Renfrow, M.B., MacKay, C.L., Chalmers, M.J., Julian, B.A., Mestecky, J., Kilian, M., Poulsen, K., Emmett, M.R., Marshall A. G., Novak, J. Analysis of O-glycan heterogeneity in IgA1 myeloma proteins by Fourier transform ion cyclotron resonance mass spectrometry: Implications for IgA nephropathy. Anal. Bioanal. Chem. 389, 1397-1407, 2007.
  21. Julian, B.A., Wittke, S., Novak, J., Good, D.M., Coon, J.J., Kellmann, M., Zürbig, P., Schiffer, E., Haubitz, M., Moldoveanu, Z., Calcatera, S.M., Wyatt, R.J., Sykora, J., Sladkova, E., Hes, O., Mischak, H., and McGuire, B.M. Electrophoretic methods for analysis of urinary polypeptides in IgA-associated renal diseases. Electrophoresis, 28, 4469-4483, 2007.
  22. Lau, K.L., Wyatt, R.J., Moldoveanu, Z., Tomana, M., Julian, B.A., Hogg, R.J., Lee, J.Y., Huang, W.-Q., Mestecky, J., Novak, J. Serum levels of galactose-deficient IgA in children with IgA nephropathy and Henoch-Schoenlein purpura. Ped. Nephrol. 22, 2067-2072, 2007.
  23. Good, D.M., Thongboonkerd, V., Novak, J., Bascands, J.-L., Schanstra, J.P., Coon, J.J., Dominiczak, A.F., Mischak, H. Proteomics of body fluids for biomarker discovery: lessons from the past hold the key to success in the future. J. Prot. Res. 6, 4549-4555, 2007.
  24. Mestecky, J., Tomana, M., Moldoveanu, Z., Julian, B.A., Suzuki, H., Matousovic, K., Renfrow, M.B., Novak, L., Wyatt, R.J., Novak, J. The role of aberrant glycosylation of IgA1 molecules in the pathogenesis of IgA nephropathy. Kidney Blood Pres. Res. 31, 29-37, 2008.
  25. Suzuki, H., Moldoveanu, Z., Hall, S., Brown, R., Vu, H.L., Novak, L., Julian, B.A., Tomana, M., Wyatt, R.J., Edberg, J.E., Alarcón, G.S., Kimberly, R.P., Tomino, Y., Mestecky, J., Novak, J. IgA1-secreting cell lines from patients with IgA nephropathy produce aberrantly glycosylated IgA1. J. Clin. Invest. 118, 629-639, 2008.
  26. Gharavi, A.G., Moldoveanu, Z., Wyatt, R.J., Barker, C.V., Woodford, S.Y., Lifton, R.P., Mestecky, J., Novak, J., Julian, B.A. Aberrant IgA1 glycosylation is inherited in familial and sporadic IgA nephropathy. J. Am. Soc. Nephrol. 19, 1008-1014, 2008. PMID: 18272841
  27. Novak, J., Julian, B.A., Tomana, M., Mestecky, J. IgA glycosylation and IgA immune complexes in the pathogenesis of IgA nephropathy. Semin. Nephrol. 28, 78-87. 2008.
  28. Rossing, K., Mischak, H., Dakna, M., Zürbig, P., Novak, J., Julian, B.A., Good, D.M., Coon, J.J., Tarnow, L., Rossing, P. Urinary proteomics in diabetes and chronic renal disease. J. Am. Soc. Nephrol. 19, 1283-1290, 2008.
  29. Coon, J.J., Zürbig, P., Dakna, M., Dominiczak, A.F., Decramer, S., Fliser, D., Frommberger, M., Golovko, I., Good, D.M., Herget-Rosenthal, S., Jankowski, J., Julian, B.A., Kellmann, M., Kolch, W., Massy, Z., Novak, J., Rossing, K., Schanstra, J.P., Schiffer, E., Theodorescu, D., Vanholder, R., Weissinger, E.M., Mischak, H., Schmitt-Kopplin, P. CE-MS analysis of the human urinary proteome for biomarker discovery and disease diagnostics. Proteomics-Clin. Appl. 2, 964-973, 2008.
  30. Suzuki, H., Suzuki, Y., Narita, I., Aizawa, M., Kihara, M., Yamanaka, T., Kanou, T., Tsukaguchi, H., Novak, J., Horikoshi, S., Tomino, Y. Toll-like receptor 9 affects severity of IgA nephropathy. J. Am. Soc. Nephrol. 9, 2384-2395, 2008. PMID: 18776126
  31. Gomes, M.M., Walls, S.B., Novak, J., Renfrow, M.B., Herr, A.B. Analysis of IgA1 N-glycosylation and its contribution to FcαRI binding. Biochemistry. 47, 11285-11299, 2008. PMID: 18826328
  32. Suzuki, H., Fan, R., Zhang, Z., Brown, R., Hall, S., Julian, B.A., Chatham, W.W., Suzuki, Y., Wyatt, R.J., Moldoveanu, Z., Lee, J.Y., Robinson, J., Tomana, M., Tomino, Y., Mestecky, J., Novak, J. Aberrantly glycosylated IgA1 in IgA nephropathy patients is recognized by IgG antibodies with restricted heterogeneity. J. Clin. Invest. 119, 1668-1677, 2009.
  33. Julian, B.A., Suzuki, H., Suzuki, Y., Tomino, Y., Spasovski, G., Novak, J. Sources of urinary proteins and their analysis by urinary proteomics for the detection of biomarkers of disease. Proteomics – Clin. Appl. 3, 1029-1043, 2009.
  34. Julian, B.A., Suzuki, H., Spasovski, G., Suzuki, Y., Tomino, Y., Novak, J. Application of Proteomic Analysis to Renal Disease in the Clinic. Proteomics – Clin. Appl. 3, 1023-1028, 2009. PMID: 20057921
  35. Lau, K., Suzuki, H., Novak, J., Wyatt, R.J. Pathogenesis of Henoch-Schönlein purpura nephritis. Ped. Nephrol. 25, 19-26, 2010.
  36. Lavigne, K.A., Woodford, S.Y., Barker, C., Julian, B.A., Novak, J., Moldoveanu, Z., Gharavi, A.G., Wyatt, R.J. Familial IgA nephropathy in southeastern Kentucky. Clin. Nephrol. 73, 115-121, 2010.
  37. Matousovic, K., Novak, J., Julian, B.A., Mestecky, J. Tissue distribution and biological activities of immune complexes are determined by their size and composition. Nephrol. Dial. Transplant. 25, 1007, 2010. PMID: 19914.
  38. Mischak, H., Kolch, W., Aivaliotis, M., Bouyssié, D., Court, M., Dihazi, H., Dihazi, G.H., Franke, J., Garin, J., de Peredo, A.G., Iphöfer, A., Jänsch, L., Lacroix, C., Makridakis, M., Masselon, C., Metzger, J., Monsarrat, B., Mrug, M., Norling, M., Novak, J., Pich, A., Pitt, A., Bongcam-Rudloff, E., Siwy, J., Suzuki, H., Thongboonkerd, V., Wang, L.-S., Zoidakis, J., Zurbig, P., Schanstra, J.P., Vlahou, A. Comprehensive human urine standards for comparability and standardization in clinical proteome analysis. Proteomics- Clin. Appl. 4, 464-478, 2010.
  39. Hu, S.L., Colvin, G.O., Rifai, A., Suzuki, H., Novak, J., Esparza, A., Farooqi, S., Julian, B.A. Glomerulonephritis after hematopoietic cell transplantation: IgA nephropathy with increased galactose-deficient-IgA1 excretion. Nephrol. Dial. Transplant. 25, 1708-1713, 2010.
  40. Mestecky, J., Raska, M., Novak, J., Alexander, R.C., Moldoveanu, Z. Antibody-mediated protection and the mucosal immune system of the genital tract: relevance to vaccine design. J. Reprod. Immunol. 85, 81-85, 2010. PMID: 20236708
  41. Wada, Y., Dell, A., Haslam, S.M., Tissot, B., Canis, K., Azadi, P., Malin Bäckström, M., Costello, C.E., Hansson, G.C., Hiki, Y., Ishihara, M., Ito, H., Kakehi, K., Karlsson, N., Kato, K., Kawasaki, N., Khoo, K.-H., Kobayashi, K., Kolarich, D., Kondo, A., Lebrilla, C., Nakano, M., Narimatsu, H., Novak, J., Novotny, M.V., Packer, N.H., Renfrow, M.B. Tajiri, M., Thomsson, K.A., Yu, S.-Y., Taniguchi, N. Comparison of methods for profiling O-glycosylation: HUPO Human Disease Glycomics/Proteome Initiative multi-institutional study of IgA1. Mol. Cell Prot. 9, 719-727 2010. PMID: 20038609
  42. Gomes, M.M., Suzuki, H., Tomana, M., Moldoveanu, Z., Mestecky, M., Julian, B.A., Novak, J., Herr, A.B. Molecular basis for the recognition of galactose-deficient O-glycans in the hinge region of IgA1 by N-acetylgalactosamine-specific snail lectins. Biochemistry. 49, 5671-5682, 2010. PMID: 20507092
  43. Kiryluk, K., Julian, B.A., Wyatt, R.J., Scolari, F., Zhang, H., Novak, J., Gharavi, A.G.. Genetic Studies of IgA Nephropathy: Past, Present, and Future. Ped. Nephrol. 25, 2257-2268, 2010. PMID: 20386929
  44. Hastings, M.C., Moldoveanu, Z., Julian, B.A., Novak, J., McGlothan, K.R., Gharavi, A.G., Wyatt, R.J. Galactose-deficient IgA1 in African Americans with IgA nephropathy: serum levels and heritability. Clin. J. Am. Soc. Nephrol. 5, 2069-2074, 2010. PMID: 20634323
  45. Good, D.M., Zürbig, P., Bauer, H.W., Behrens, G., Coon, J.J., Dakna, M., Dominiczak, A.F., Decramer, S., Ehrich, J.H.H., Fliser, D., Frommberger, M., Ganser, A., Girolami, M.A., Golovko, I., Gwinner, W., Haubitz, M., Rosenthal, S.H., Jahn, H., Jankowski, J., Jerums, G., Julian, B.A., Kellmann, M., Kliem, V., Krolewski, A., Kolch, W., Krolewski, A., Luppi, M., Massy, Z., Melter, M., Neusüss, C., Novak, J., Peter, K., Rossing, K., Rupprecht, H., Schanstra, J.P., Schiffer, E., Stolzenburg, J.-U., Tarnow, L., Theodorescu, D., Thongboonkerd, V., Vanholder, R., Weissinger, E.M., Mischak, H., Schmitt-Kopplin, P. Naturally occurring human urinary peptides for use in diagnosis of chronic kidney disease. Mol. Cell. Proteomics. 9, 2424-2437, 2010. PMID: 20616184
  46. Mischak, H., Allmaier, G., Apweiler, R., Attwood, T., Baumann, M., Benigni, A., Bennett, S.E., Bischoff, R., Bongcam-Rudloff, E., Capasso, G., Coon, J.J., D'Haese, P., Dominiczak, A.F., Dakna, M., Dihazi, H., Ehrich, J.H., Fernandez-Llama, P., Fliser, D., Frokiaer, J., Garin, J., Girolami, M., Hancock, W.S., Haubitz, M., Hochstrasser, D., Holman, R., Jankowski, J., Julian, B.A., Klein, J.B., Kolch, W., Luider, T., Massy, Z., Mattes, W.B., Molina, F., Monsarrat, B., Novak, J., Peter, K., Rossing, P., Sánchez-Carbayo, M., Schanstra, J.P., Semmes, O.J., Spasovski, G., Theodorescu, D., Thongboonkerd, V., Vanholder, R., Veenstra, T., Weissinger, E., Yamamoto, T., Vlahou A. Recommendations for biomarker identification and classifier validation in clinical proteomics. Science Translational Medicine. 2, 46ps42, 2010.
  47. Takahashi, K., Wall, S.B., Suzuki, H., Smith, IV, A.D., Hall, S., Poulsen, K., Kilian, M., Julian, B.A., Mestecky, J., Novak, J., Renfrow, M.B. Clustered O-glycans of IgA1: Defining macro- and micro-heterogeneity by use of electron capture/transfer dissociation. Mol. Cell. Proteomics. 9, 2545-2557, 2010. PMID: 20823119
  48. Lindfors, K., Suzuki, H., Novak, J., Collin, P., Saavalainen, P., Koskinen, L.L.E., Mäki, M., Kaukinen, K. Galactosylation of serum IgA1 O-glycans in celiac disease. J. Clin. Immunol. 31, 74-79, 2011. PMID: 20938724
  49. Gharavi, A.G., Kiryluk, K., Choi, M., Li, Y., Hou, P., Xie, J.Y., Sanna-Cherchi, S., Men, C.J., Julian, B.A., Wyatt, R.J., Novak, J., Wang, H., Lv, J., Zhu, L., Wang, Z.-H., Yasuno, K., Gunel, M., Mane, S., Umlauf, S., Tikhonova, I., Savoldi, S., Magistroni, R., Ghiggeri, G.M., Lugani, F., Ravani, P., Ponticelli, C., Allegri, L., Boscutti, G., Frasca, G., Izzi, C., Viola, F., Prati, E., Salvadori, M., Gesualdo, L., Amoroso, A., Scolari, F., Chen, N., Zhang, H., Lifton, R.P. Genome-wide association study identifies five susceptibility loci for IgA nephropathy, the most common form of glomerulonephritis. Nat. Genet. 43, 321-327, 2011. PMID: 21399633
  50. Kiryluk, K., Moldoveanu, Z., Sanders, J.T., Eison, T.M., Suzuki, H., Julian, B.A., Novak, J., Gharavi, A.G., Wyatt, R.J. Aberrant glycosylation of IgA1 is inherited in pediatric IgA nephropathy and Henoch-Schoenlein purpura nephritis. Kidney Int. 80, 79-87, 2011. PMID: 21326171
  51. Camilla, R. Suzuki, H., Daprà, V., Loiacono, E., Peruzzi, L., Amore, A., Ghiggeri, G.M., Mazzucco, G., Scolari, F., Gharavi, A.G., Appel, G., Troyanov, S., Novak, J., Julian, B.A., Coppo, R. Oxidative stress and aberrantly glycosylated IgA1 as risk factors for progression of IgA nephropathy. Clin. J. Am. Soc. Nephrol. 6, 1903–1911, 2011. PMID: 21784819
  52. Suzuki, H., Kiryluk, K., Novak, J., Moldoveanu, Z., Herr, A.B., Renfrow, M.B., Wyatt, R.J., Scolari, F., Mestecky, J., Gharavi, A.G., Julian, B.A. The pathophysiology of IgA nephropathy. J. Am. Soc. Nephrol. 22, 1795-1803, 2011. PMID: 219490
  53. McCarthy, D.D., Kujawa, J., Wilson, C., Papandile, A., Poreci, U., Porfilio, E.A., Ward, L., Lawson, M.A.E., Macpherson, A.J., McCoy, K.D., Pei, Y., Novak, L., Lee, J.Y., Julian, B.A., Novak, J., Ranger, A., Gommerman, J.L., Browning, J.L. Mice over-expressing BAFF develop a commensal flora-dependent, IgA-associated nephropathy. J. Clin. Invest. 121, 3991-4002, 2011. PMID: 21881212
  54. Novak, J., Kafkova, L., Suzuki, H., Tomana, M., Matousovic, K., Brown, R., Hall, S., Sanders, J.T., Eison, T.M., Moldoveanu, Z., Novak, L., Novak, Z., Mayne, R., Julian, B.A., Mestecky, J., Wyatt, R.J. IgA1 immune complexes from pediatric patients with IgA nephropathy activate human mesangial cells. Nephrol. Dial. Transplant. 26, 3451-3457, 2011. PMID: 21828345
  55. Papeta, N., Kiryluk, K., Patel, A., Sterken, R., Kacak, N., Snyder, H.J., Mhatre, A.N., Julian, B.A., Wyatt, R.J., Novak, J., Wyatt, C.M., Ross, M.J., Winston, J.A., Klotman, M.E., Cohen, D.J., Appel, G.B., D'Agati, V.D., Klotman, P.E., Gharavi, A.G. APOL1 genetic variants are associated with susceptibility to focal segmental glomerulosclerosis and HIV-1-associated nephropathy but not IgA nephropathy in African-Americans. J. Am. Soc. Nephrol. 22, 1991-1996, 2011. PMID: 21997397
  56. Horynová, M., Takahashi, K., Hall, S., Renfrow, M.B., Novak, J., Raska, M., Production of N-acetylgalactosaminyl-transferase 2 (GalNAc-T2) fused with secretory signal Igκ in insect cells. Protein Expr. Purif. In Press. 2011. PMID: 22033505
  57. Takahashi, K., Smith IV, A.D., Poulsen, K., Kilian, M., Julian, B.A., Mestecky, J., Novak, J., Renfrow, M.B. Naturally Occurring Structural Isomers in Serum IgA1 O-Glycosylation. J. Prot. Res. In Press. 2011.
  58. He, M., Novak, J., Julian, B.A., Herr, A.E. Microfluidic lectin blotting: Towards the assessment of aberrantly glycosylated serum IgA1 in IgA nephropathy. J. Am. Chem. Soc. In Press. 2011.

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