Our research group is based at the University of Leicester and the John Wall's Renal Unit at Leicester General Hospital. The research group is a dynamic and proactive team comprising clinicians, research scientists, BSc, MSc and PhD students and technicians. We are part of the larger renal research group at the University, within the Department of Infection, Immunity and Inflammation.
Leicester is a vibrant and multicultural city in the East Midlands, right in the centre of the UK, an hour by train to London and with direct rail and motorway networks connecting it with the rest of the UK. Famous for its rugby team (Leicester Tigers), cheeses (Red Leicester and Stilton), Indian restaurants (along the Melton Road), and its IgA nephropathy research, Leicester is an exciting place in which to work and live for the renal physician and scientist.
Our research integrates molecular and cell biology and immunology. The Renal Research laboratories are well-equipped and there is also easy access to resources within the wider university. We have well-established collaborations with other research groups. We have a large cohort of patients with IgAN who are enthusiastic to participate in our research and in addition, we have a bank of patient serum and urine samples collected over the last 20 years. Our work is supported by our local charity the Kidney Care Appeal.
• Effect of IgA structure on disease pathogenesis
• Biomarkers for risk of progressive renal disease
• Mesangial IgA receptors
• The effect of mucosal infection on disease pathogenesis
John Walls Renal Unit
Leicester General Hospital
1. Boyd JK, Cheung CK, Molyneux K, Feehally J, Barratt J. An update on the pathogenesis and treatment of IgA nephropathy. Kidney International [Internet]. 2012 Feb 8 [cited 2012 Feb 23]; Available from: http://www.ncbi.nlm.nih.gov/pubmed/22318424
2. Coppo R, Troyanov S, Camilla R, Hogg RJ, Cattran DC, Cook HT, et al. The Oxford IgA nephropathy clinicopathological classification is valid for children as well as adults. Kidney Int. 2010 May;77(10):921–7.
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4. Cattran DC, Coppo R, Cook HT, Feehally J, Roberts ISD, Troyanov S, et al. The Oxford classification of IgA nephropathy: rationale, clinicopathological correlations, and classification. Kidney Int. 2009 Sep;76(5):534–45.
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7. Smith AC, Molyneux K, Feehally J, Barratt J. O-glycosylation of serum IgA1 antibodies against mucosal and systemic antigens in IgA nephropathy. J. Am. Soc. Nephrol. 2006 Dec;17(12):3520–8.
8. Allen AC, Bailey EM, Brenchley PE, Buck KS, Barratt J, Feehally J. Mesangial IgA1 in IgA nephropathy exhibits aberrant O-glycosylation: observations in three patients. Kidney Int. 2001 Sep;60(3):969–73.