Saturday, February 16, 2019

Paris, France



Bichat Medical School of Paris Diderot University - INSERM Unit 699
Bichat Hospital 46, rue Henri Huchard
75018 PARIS

Team Title: Immunoreceptors and renal immunopathology

Leader: Renato MONTEIRO

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Members Equivalent full-time
Pr Renato Monteiro (Professor in Immunology) 0.5
Dr Colette Kanellopoulos-Langevin (Senior Scientist - CNRS) 1
Dr Laureline Berthelot (Senior Scientist - Inserm) 1
Dr Philippe Verbeke (Assistant Professor) 1
Pr François Vrtovsnik (Professor in Nephrology) 0.25
Pr Georges Deschenes (Professor in Nephrology) 0.25
Pr Vicent Ravery (Professor in Urology) 0.25
Dr Evangéline pillebout (MD) 0.25
Dr Martin Flamant (Assistant Professor) 0.25
Dr Sanae Ben Mkaddem (post-doc) 1
Dr Agnès Jamin (post-doc) 1
Nicholas Heming (PhD student) 1
Elisabetta Rossato (PhD student) 1
Christina Papista (PhD student) 1
Stéphane Prieto (PhD student) 1
Marie-Bénédicte Le Stang (Master student) 1
Erwn Boedec (Engeneer) 1
Virgina Sauvaget (Technician) 1
Aurélie Gestin (Technician) 1
Julie Bex-Coudrat (Animal keeper) 0.5

Atip-Avenir Group:
Dr Cécilia Chassin (CDD-ATIP-Avenir) 1
Dr Alain Vandevalle (Senior Scientist - Inserm) 0.25
Emilie Touneur (PhD student) 1
Marcelle Bens (Engeneer) 1


Our team focuses on the immune mechanisms involved in glomerulonephitis notably in IgA nephropathy (IgAN), one of the first causes of renal failure worldwide. The team has a fundamental immunological background on immunoglobulins and their receptors as well as in renal immunopathology. Our projects focus on four axes: the search of prognostic markers of IgAN, the study of factors influencing the development of glomerulonephritides, the determination of the miRNA involved in glomerulonephritides and the modulation of renal inflammation through ITAM-bearing Fc receptors. The team has a large experience with transgenesis and mouse models of IgAN as well as in translational medicine.

Selected publications:
1. Monteiro R.C., Halbwachs-Mecarelli L., Roque-Barreira M.C., Noël L.H., Berger J. and Lesavre P.: Charge and size of mesangial IgA in IgA nephropathy. Kidney Int 28: 666-671, 1985.
2. Monteiro R.C., Kubagawa H., Cooper M.D. Cellular distribution, regulation and biochemical nature of an Fcα receptor in humans. J Exp Med 171: 597-613, 1990
3. Grossetête B, Launay P, Lehuen A, Jungers P, Bach JF, Monteiro RC. Down-regulation of Fca receptors on blood cells of IgA nephropathy patients: Evidence for a negative regulatory role of serum IgA. Kidney Int. 53: 1321-1335, 1998.
4. Launay P., Grossetete B., Arcos-Fajardo M., Gaudin E., Torres S., Beaudoin L., Patey-Mariaud de Serre N., Lehuen, A., Monteiro R.C. Fcα receptor (CD89) mediates the development of Immunoglobulin A (IgA) nephropathy (Berger's Disease): Evidence for pathogenic soluble receptor- IgA complexes in patients and CD89 transgenic mice. J Exp Med 191: 1999-2009, 2000
5. Moura I.C., Centelles M.N., Arcos-Fajardo M., Malheiros D.M., Collawn J.F., Cooper M.D., Monteiro R.C. Identification of the transferrin receptor as a novel immunoglobulin A1 receptor and its enhanced expression on mesangial cells in IgA nephropathy. J Exp Med 194: 417-42, 2001
6. Monteiro RC, Moura IC, Launay P, Tsuge T, Haddad E, Benhamou M, Cooper MD, Arcos-Fajardo M. Pathogenic significance of IgA receptor interactions in IgA nephropathy. Trends Mol Med. 8(10):464-8, 2002. Review.
7. Monteiro RC & van de Winkel JGJ. IgA Fc receptors. Annu Rev Immunol 21 : 177-204, 2003. Review.
8. Moura I.C., Arcos-Fajardo M., Sadaka C., Leroy V., Benhamou M., Novak J., Vrtovsnik F., Haddad E., Chintalacharuvu K.R. Monteiro R.C. Glycosylation and size of IgA are essential for interaction with mesangial transferrin receptor in IgA nephropathy J Am Soc Nephol 15: 622-634, 2004.
9. Pasquier, B, Launay P, Kanamaru Y, Moura IC, Pfirsch S, Ruffié C, Hénin D, Benhamou M, Pretolani M, Blank U, Monteiro RC. Identification of FcαRI as an inhibitory receptor that controls inflammation: Dual role of FcRγ ITAM. Immunity 22: 31-39, 2005
10. Moura, IC, Arcos-Fajardo M, Gdoura A, Leroy V, Sadaka C, Mahlaoui N, Lepelletier Y, Vrtovsnik F, Haddad E, Benhamou M, Monteiro RC. Engagement of transferrin receptor by polymeric IgA1: Evidences for a positive feedback loop involving increased receptor expression and mesangial cell proliferation in IgA nephropathy. J Am Soc Nephol 16:2667-76, 2005.
11. Kanamaru Y, Arcos-Fajardo M, Moura IC, Tsuge T, Cohen H, Essig M, Vrtovsnik F, Loirat C, Peuchmaur M, Beaudoin L, Launay P, Lehuen A, Blank U, Monteiro RC. Fc alpha receptor I activation induces leukocyte recruitment and promotes aggravation of glomerulonephritis through the FcR gamma adaptor. Eur J Immunol. 37(4):1116-28, 2007.
12. Pinheiro da Silva F, Aloulou M, Skurnik D, Benhamou M, Andremont A, Velasco IT, Chiamolera M, Verbeek JS, Launay P, Monteiro RC. CD16 promotes E. coli sepsis through an FcRγ inhibitory pathway that prevents phagocytosis and facilitates inflammation. Nat Med 13:1368-74, 2007.
13. Matysiak-Budnik T, Moura IC, Arcos-Fajardo M, Lebreton C, Ménard S, Candalh C, Ben-Khalifa K, Dugave C, Tamouza H, van Niel G, Bouhnik Y, Lamarque D, Chaussade S, Malamut G, Cellier C, Cerf-Bensussan N, Monteiro RC*, Heyman M*. Secretory IgA mediates retrotranscytosis of intact gliadin peptides via the transferrin receptor in celiac disease. J Exp Med. 205:143-54, 2008. *co-last authors
14. Moura IC, Benhamou M, Launay P, Vrtovsnik F, Blank U, Monteiro RC. The glomerular response to IgA deposition in IgA nephropathy. Semin Nephrol. 28(1):88-95, 2008. Review.
15. Coulon S, Dussiot M, Grapton D, Maciel TT, Wang PH, Callens C, Tiwari MK, Agarwal S, Fricot A, Vandekerckhove J, Tamouza H, Zermati Y, Ribeil JA, Djedaini K, Oruc Z, Pascal V, Courtois G, Arnulf B, Alyanakian MA, Mayeux P, Leanderson T, Benhamou M, Cogné M, Monteiro RC*, Hermine O*, Moura IC*. Polymeric IgA1 controls erythroblast proliferation and accelerates erythropoiesis recovery in anemia. Nat Med 17:1456-65, 2011. *co-last author
16. Tissandié E, Morelle W, Berthelot L, Vrtovsnik F, Daugas E, Walker F, Lebrec D, Trawalé JM, Francoz C, Durand F, Moura IC, Paradis V, Moreau R, Monteiro RC. Both IgA nephropathy and alcoholic cirrhosis feature abnormally glycosylated IgA1 and soluble CD89-IgA and IgG-IgA complexes: common mechanisms for distinct diseases. Kidney Int 80:1352-63, 2011.
17. Aloulou M, Ben Mkaddem S, Biarnes-Pelicot M, Boussetta T, Souchet H, Rossato E, Benhamou M, Crestani B, Zhu Z, Blank U, Launay P, Monteiro RC. IgG1 and IVIg induce inhibitory ITAM signaling through FcγRIII controlling inflammatory responses. Blood 119:3084-96, 2012
18. Berthelot L, Papista C, Maciel TT, Biarnes-Pelicot M, Tissandie E, Wang PH, Tamouza H, Jamin A, Bex-Coudrat J, Gestin A, Boumediene A, Arcos-Fajardo M, England P, Pillebout E, Walker F, Daugas E, Vrtosvnik F, Flamant M, Benhamou M, Cogné M, Moura IC, Monteiro RC. Transglutaminase is essential for IgA nephropathy development acting through IgA receptors. J Exp Med. 209:793-806, 2012
19. Tamouza H, Chemouny J, Kafkova L, Berthelot L, Flamant M, Vrtovsnik F, Demion M, Mesnard L, Walker F, Julian B, Tissandie E, Tiwari M, Camara NO, Benhamou M, Novak J, Monteiro RC, Moura IC. IgA1 immune complex-mediated activation of MAPK/ERK kinase pathway in mesangial cells is associated with glomerular damage in IgA nephropathy. Kidney Int in press.


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